Description
NAD⁺ is a pyridine nucleotide coenzyme found in all living cells, where it plays a central role in oxidation-reduction (redox) reactions, acting as an electron carrier in metabolic pathways such as glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation. It exists in oxidized (NAD⁺) and reduced (NADH) forms and is essential for ATP production.
Beyond its role in energy metabolism, NAD⁺ is a critical substrate for several enzyme families, including sirtuins, PARPs (poly ADP-ribose polymerases), and CD38, which are involved in DNA repair, gene expression, cellular signaling, and immune responses. Declining levels of NAD⁺ have been associated with aging, neurodegeneration, and metabolic disorders, making it a major focus of longevity and regenerative medicine research.
Studies also explore NAD⁺ supplementation and precursors such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) to restore intracellular NAD⁺ levels and enhance mitochondrial and cellular resilience. Its broad biochemical relevance makes NAD⁺ a cornerstone of research in cell biology, metabolism, and age-related disease.
I’ve been using NAD+ supplements for two months, and the results have been incredible. I used to feel drained all the time, but now my energy levels are much higher, and I’m more focused throughout the day. My workouts have gotten better too—I can push harder and recover faster.
I’m also sleeping more soundly, and my mood has definitely improved. There’s even a noticeable change in my skin—it looks smoother and more hydrated. Overall, I feel more vibrant and youthful. I’m excited to keep using it and see even more benefits. Highly recommend for anyone looking to boost energy and mental clarity!